Exploratory Urinary Proteomic Profiling in Pregnancies with Fetal Aneuploidies: Molecular Insights into Maternal-Fetal Metabolic Communication.

ABSTRACT: Maternal-fetal communication involves complex molecular exchanges that can be perturbed by chromosomal abnormalities. Despite the growing use of omics approaches in prenatal research, maternal urine remains underexplored as a non-invasive source of molecular information reflecting both systemic and pregnancy-specific processes. This study performed an exploratory, label-free mass spectrometry-based proteomic analysis of maternal urine from pregnancies with normal karyotype (n = 15) and those affected by fetal aneuploidy (n = 9; trisomy 21, 18, 13, or monosomy X). A total of 861 proteins were identified across all samples, of which 42 significantly differed between groups (p ≤ 0.05, |fold change| ≥ 1.2). Ten proteins, including TFF1, TFF3, KRT76, CD300, PVR, VWA1, FBLN1

SUBMITTER: Jurca RL 

PROVIDER: S-EPMC12731864 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature