Hepatoblastoma Cell Lines: Past, Present and Future.

ABSTRACT: Hepatoblastoma (HB), the most common pediatric liver malignancy, tends to be highly curable although advanced or recurrent disease has less favorable outcomes. Because patients are invariably <3-4 years of age, chemotherapies can cause significant long-term morbidities. Immortalized HB cell lines could be of great utility for drug screening, for the identification of novel therapeutic susceptibilities, and for studies requiring highly regulated and/or rapidly changing in vitro environments. However, HB research is hampered by a paucity of these lines that could be used for such purposes, with only two human cell lines being readily available, neither of which represents the most common HB molecular subtypes. Recently, immortalized cell lines have been derived from murine HBs that are drive

SUBMITTER: Prochownik EV 

PROVIDER: S-EPMC12731888 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature