Preliminary Evidence Linking Maternal Sleep-Disordered Breathing During Pregnancy to Early Childhood Development: A 3-Year Pilot Cohort Study in Japan.

ABSTRACT:

Background/objectives

Obstructive sleep apnea (OSA) during pregnancy may reduce maternal oxygenation, cause sleep fragmentation, and influence offspring development. This pilot study explored potential associations between OSA during pregnancy and child outcomes at age 3.

Methods

Pregnant women aged 23-48 years who underwent home sleep apnea testing (HSAT) at 28-32 weeks of gestation between June 2021 and July 2025 were enrolled. OSA was defined as an apnea-hypopnea index (AHI) ≥ 5. Mothers and children were prospectively followed until the child reached 3 years of age. Children's developmental levels (motor, cognitive/adaptive, language/social, and total) were evaluated using the New K-Type Developmental Test. Anthropometric measures (height, weight, and head circumference)

SUBMITTER: Takenouchi Y 

PROVIDER: S-EPMC12731920 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature