Environmental and Rhizosphere Microbiome Drivers of Metabolic Profiles in <i>Gastrodia elata</i>: An Integrative Analysis of Soil, Metabolomics and Anti-Inflammatory Readouts.

ABSTRACT:

Background

Gastrodiae Rhizoma, the dried tuber of Gastrodia elata Bl. (Orchidaceae), is a traditional Chinese medicinal (TCM) and edible plant. Its quality formation is closely associated with rhizosphere microorganisms; however, the specific underlying mechanisms remain unclear.

Methods

Tubers and rhizosphere soils were collected from seven major production regions of G. elata. Soil physicochemical properties were analyzed, and integrative analyses combining soil microbiome and untargeted metabolome profiling were conducted. The anti-inflammatory activity of G. elata extracts was evaluated using a RAW264.7 macrophage model. Multivariate statistical approaches, including OPLS-DA and correlation network analysis, were used to decipher relationships among

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12731933 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature