Evaluation of Potential Anti-Diabetic Synbiotic Formulation of <i>Lacticaseibacillus rhamnosus</i> BST.L-601 Using db/db Mice.

ABSTRACT: Probiotics have been studied for their potential to treat chronic diseases. This study examined the use of Lacticaseibacillus rhamnosus BST.L-601 as an anti-diabetic symbiotic with sweet potato for fermentation. The medium supplemented with sweet potato showed increased productivity and enhanced storability. The anti-diabetic effect of fermented BST.L-601 was evaluated using the C2C12 myotube and a type 2 diabetes mellitus (T2DM)-induced db/db (Lepr^db/Lepr^db) mouse model. Treatment with heat-killed BST.L-601 increased glucose uptake by 125% and α-glucosidase inhibition in a dose-dependent manner without cytotoxicity for myotubes. 8 weeks of oral administration of BST.L-601 led to anti-diabetic activities in various biomarkers in the mouse model, including lower

SUBMITTER: Choe H 

PROVIDER: S-EPMC12731962 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature