Colorectal Cancer in the U.S., 1999-2021: Declining Rates, Rising Concerns, and Persistent Disparities.

ABSTRACT: Background: Colorectal cancer (CRC) incidence and mortality have declined in the United States over the past two decades, yet disparities persist by age, sex, race/ethnicity, and geography. To characterize population-level survival signals, we examined trends in age-adjusted incidence rates (AAIR), mortality rates (AAMR), and the mortality-to-incidence ratio (AAMIR) from 1999 to 2021, stratified by key subgroups. Methods: This retrospective analysis utilized de-identified data from the CDC WONDER United States Cancer Statistics database, encompassing incident CRC cases (SEER codes 21041-21052) and deaths (ICD-10 codes C18-C20) in adults aged 20 years and older. Age-adjusted rates (per 100,000, 2000 U.S. standard population) and AAMIR were calculated using Stata 17.0. Joinpoin

SUBMITTER: Bin Abdul Ghaffar Q 

PROVIDER: S-EPMC12731979 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature