Early Menarche and Hypertension Among Postmenopausal Women: The Mediating Role of Obesity.

ABSTRACT:

Background/objectives

Cardiovascular diseases are the leading cause of mortality worldwide and are strongly influenced by obesity and hypertension. Age at menarche has been proposed as an early marker of cardiometabolic risk, but evidence in postmenopausal women is inconsistent, particularly in Mexico. We aimed to evaluate the association between early menarche and obesity and hypertension in postmenopausal women, and to examine whether obesity mediates this relationship.

Methods

We conducted a cross-sectional study based on a retrospective review of 462 medical records of postmenopausal women who attended a tertiary hospital in Mexico City between January 2023 and August 2024. Early menarche was defined as <12 years. Obesity and hypertension were identified from records. As

SUBMITTER: Ibanez-Garcia EC 

PROVIDER: S-EPMC12732153 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature