Comparative Multi-Omics Analysis Identifies Shared Transcriptomic Signatures and Therapeutic Targets in Alzheimer's, Parkinson's, and Huntington's Diseases.

ABSTRACT: Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are major neurodegenerative disorders that share certain pathological features but differ in their genetic etiology and clinical presentation. Their potential molecular intersections remain incompletely understood. In this research, we conducted a comparative transcriptomic analysis using postmortem brain RNA-seq datasets from AD (GSE53697), PD (GSE68719), and HD (GSE64810) to identify shared and disease-specific transcriptional signatures. Differentially expressed genes (DEGs) were determined and functionally characterized through Gene Ontology (GO) enrichment. Protein-protein interaction (PPI) networks were generated using STRING and visualized in Cytoscape to identify central hub genes, followed by gene-di

SUBMITTER: Alharbi LI 

PROVIDER: S-EPMC12732164 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature