Individualised dose mapping uncertainty estimation in the reirradiation setting.

ABSTRACT:

Background and purpose

Deformable image registration (DIR) allows assessing radiation doses of previous treatment courses in reirradiation planning scans. However, DIR can introduce uncertainties in dose mapping. Estimating these uncertainties for individual patients remains a key challenge. We developed an individualised approach to estimate uncertainties in dose mapping using a commercially available treatment planning system.

Materials and methods

For 54 patients who underwent reirradiation (27 head and neck, H&N, and 27 lung cases), we performed 16 DIRs per patient. We assessed each DIR geometrically using the mean distance to agreement (mDTA) between mapped contours and the corresponding structures of 30 to 34 organs at risk (OARs). We then estimated dose mapping uncert

SUBMITTER: Thiong'o CM 

PROVIDER: S-EPMC12732311 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature