From sonochemical synthesis to predictive modeling: Unraveling the antioxidant properties of La-doped CeO₂ nanoparticles.

ABSTRACT: This study introduces a novel combination of sonochemical synthesis and machine learning (ML) modeling to analyze the effect of Lanthanum (La) doping on the biological properties of cerium oxide (CeO₂) nanoparticles with various La concentrations (0, 1, 5, and 10 at.%). Ultrasonic-assisted synthesis enabled La incorporation into the CeO₂ lattice, resulting changes in crystallinity, lattice parameters, and surface features. Detailed characterization confirmed successful doping and indicated stable nanoparticle suspensions with controlled size ranges. Sonochemical synthesis promoted the oxidation of Ce³⁺ to Ce⁴⁺. Biological testing revealed low cytotoxicity across various cell lines (HepG-2, 3 T3-L1, Caco-2, and U87) and increased antioxidant activ

SUBMITTER: Mejia-Mendez JL 

PROVIDER: S-EPMC12732317 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature