The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia.

ABSTRACT: The relationship between early pregnancy lipid indicators and gestational diabetes mellitus (GDM) or pre-eclampsia (PE) remains incompletely elucidated. This prospective cohort study explored the associations between seven lipid indicators and GDM and PE among 32,411 pregnant participants. The results suggested that triglycerides (TGs), total cholesterols (TCs), and remnant cholesterols (RCs) were positively associated with both GDM and the composite outcome (GDM/PE). For GDM, compared with the lowest quartile, the highest quartile had odds ratios (ORs) of 1.646 (95% confidence interval [95% CI]: 1.363, 1.988) for TGs, 1.654 (95% CI: 1.241, 2.205) for TCs, and 1.396 (95% CI: 1.189, 1.640) for RCs. For GDM/PE, the corresponding ORs in the highest versus lowest quartile were 1.564 (95% CI: 1

SUBMITTER: Tang J 

PROVIDER: S-EPMC12732318 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature