Phenotypic Characterization and Genomic Mining of Uric Acid Catabolism Genes in <i>Lactiplantibacillus plantarum</i> YC.

ABSTRACT: This study presents the phenotypic characterization and genomic mining of uric acid catabolism genes in Lactiplantibacillus plantarum YC, a novel food-grade lactic acid bacterium isolated from traditional fermented vegetables with potent uric acid-lowering activity. YC is non-hemolytic, catalase- and gelatinase-negative, exhibits strong adhesion and broad antibacterial activity, and degrades 29.22% of uric acid in vitro, along with complete (100%) degradation of inosine and guanosine. Whole-genome sequencing revealed a 3,214,448 bp chromosome encoding 3026 protein-coding genes. Comparative genomics-based functional annotation highlighted abundant CAZy-related genes and antimicrobial factors, including lysozyme and monooxygenase. Crucially, genomic mining identified a complete uric a

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12732358 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature