Global Salivary Proteomic Profiling of Individuals with the Co-Occurrence of Type 2 Diabetes Mellitus, Dyslipidemia, and Periodontitis.

ABSTRACT: Human whole saliva contains informative proteins related to disease processes and is important for oral cavity homeostasis. The aim of this study was to investigate the global salivary proteomic profile, including functional enrichment analysis of individuals affected by combinations of poorly/well-controlled type 2 diabetes mellitus (T2DM), dyslipidemia (DL), and periodontitis (P) for the identification of potential disease biomarkers. Biochemical and periodontal evaluations were performed on 150 subjects divided into five groups according to disease combinations. Unstimulated saliva was collected, and proteomic analysis was performed using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS). Results were obtained by searching for the Homo sapiens databas

SUBMITTER: Scarel-Caminaga RM 

PROVIDER: S-EPMC12732424 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature