Comparative Evaluation of Spreadability Measurement Methods for Topical Semisolid Formulations/A Scoping Review.

ABSTRACT:

Background

Spreadability is a critical performance attribute for semisolid formulations, influencing patient compliance, dose uniformity, and product acceptability. Despite its importance, there is no standardized method for its assessment across pharmaceutical and cosmetic applications.

Objective

This review uniquely integrates systematic literature mapping with an experimental comparison of five spreadability assessment techniques, providing evidence-based recommendations for harmonizing protocols and improving reproducibility in semisolid formulation testing.

Methods

A systematic search of PubMed, Scopus, and Web of Science identified 211 records, of which 14 studies met the inclusion criteria. Techniques reviewed included parallel-plate, slip-and-drag, rheometry (

SUBMITTER: Al-Barghouthy EY 

PROVIDER: S-EPMC12732428 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature