Polymorphism of the <i>RNF165</i> Gene in American Mink (<i>Neogale vison</i>) as a Potential Factor Responsible for Resistance to Infection with the Aleutian Mink Disease Virus.

ABSTRACT: Background: Advances in American mink (Neogale vison) genomics have identified candidate genes linked to disease resistance, including RNF165, which is involved in immune response and virus-host interactions. Objectives: This study aimed to characterize genetic variation within the RNF165 (Ring Finger Protein 165) gene in farmed and wild mink to identify polymorphisms potentially associated with resistance to Aleutian mink disease virus (AMDV). Methods: Two groups of mink were analyzed: farmed animals from Latvia (n = 50) and wild animals (n = 20) from Poland. The presence of viral DNA was verified by PCR amplification targeting the VP2 and NS1 viral protein genes. To assess polymorphism within RNF165, primers spanning e

SUBMITTER: Mazurkiewicz I 

PROVIDER: S-EPMC12732447 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature