Formulation of PVA Hydrogel Patch as a Drug Delivery System of Albumin Nanoparticles Loaded with Curcumin.

ABSTRACT: Curcumin is a widely researched natural molecule due to its abundance of pharmacological effects, such as antioxidant, antitumor, anti-inflammatory, etc. The main limitation of curcumin, however, is its low aqueous solubility, which worsens its biopharmaceutical characteristics. The aim of this study was to encapsulate curcumin in albumin nanoparticles and to subsequently incorporate them into a polyvinyl alcohol patch, resulting in a new drug formulation for skin application. The nanoparticles were characterized by a small mean diameter of approximately 162 nm, a narrow size distribution, and a negative zeta potential. TEM confirmed the small size of the nanoparticles. The ratio between the drug and albumin was optimized, achieving approximately 88% encapsulation efficiency. Protein-ligan

SUBMITTER: Radeva L 

PROVIDER: S-EPMC12732668 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature