Drug Repurposing in Glioblastoma Using a Machine Learning-Based Hybrid Feature Selection Approach.

ABSTRACT: Glioblastoma (GBM) is a fatal and aggressive form of brain cancer, described by rapid progression, poor prognosis, and limited treatment options. This study aims to apply a hybrid of two popular feature selection methods for the categorization of drug sensitivity features in GBM versus other cancer cell lines by employing a rank-based weighting combination scheme to identify discriminative drug compound feature sets. This approach is necessary to reduce dimensionality and enhance classification performance while increasing the interpretability of the prediction model. The experimental results indicate that the utilized machine learning (ML)-driven feature selection approach achieves more than 95% accuracy value and obtains less than or equal to 11 selected features for each drug sensitivit

SUBMITTER: Tasci E 

PROVIDER: S-EPMC12732686 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature