The Function and Role of Intercellular Adhesion Molecule 2 in Dental Pulp Cells and Tissue.

ABSTRACT: Direct pulp capping using mineral trioxide aggregate (MTA) is commonly used to preserve dental pulp tissue, but the molecular mechanisms underlying reparative dentin formation during this procedure and the restoration of dental pulp homeostasis remain unclear. To elucidate these mechanisms, we investigated the expression and function of intercellular adhesion molecule 2 (ICAM2) in dental pulp cells and tissue. ICAM2 expression in human dental pulp cells (HDPCs) was confirmed by the gene and protein expression analysis. ICAM2 expression during reparative dentin formation after direct pulp capping was investigated using a rat direct pulp capping model. The effect of ICAM2 on odontoblast-like differentiation of HDPCs was assessed using siRNA and magnetic cell sorting (MACS). The gene and prot

SUBMITTER: Tashita K 

PROVIDER: S-EPMC12732756 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature