Fn14-Targeted Gold Nanorods for Augmenting Laser Thermal Therapy for High-Grade Gliomas.

ABSTRACT: Glioblastoma (GBM) is a highly aggressive and invasive brain tumor. Tumor recurrence after standard surgery, chemotherapy, and radiation is nearly universal. Unfortunately, only around 25% of GBM patients undergo repeat surgery. Laser interstitial thermal therapy (LITT) is a promising strategy to treat patients with inoperable or recurrent GBM. While advances in magnetic resonance thermometry and laser probe cooling systems have provided significant safety improvements, the full potential of laser thermal therapy is still hindered by the lack of selective targeting of GBM cells. Gold nanorods (GNR) are attractive plasmonic antennas that can efficiently convert laser energy to localized heat for hyperthermal therapy and can be used as contrast agents for computed tomography (CT) imaging. He

SUBMITTER: Pang S 

PROVIDER: S-EPMC12732764 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature