Deciphering the Role of ADAMTS6 in the Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells.

ABSTRACT: A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6) is an extracellular matrix (ECM) protease that promotes the invasion of lung adenocarcinoma (LUAD) cells. Herein, we investigate its role in epithelial-mesenchymal transition (EMT), a process that drives metastasis and drug resistance in LUAD. Re-analysis of microarray and RNA sequencing data from LUAD cells revealed that during EMT, TGF-β1 increased ADAMTS6 expression, presumably through the SMAD pathway, as SMAD2 loss completely blocked this effect. Moreover, ADAMTS6 was shown to occupy hub positions within TGF-β1-associated gene networks. Using additional datasets, we found that ADAMTS6 expression increased under other EMT-inducing conditions, including IL-1β induction and acquired gefitinib

SUBMITTER: Odarenko KV 

PROVIDER: S-EPMC12732811 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature