Flavonoid-Rich Extract from <i>Bombyx batryticatus</i> Alleviate LPS-Induced Acute Lung Injury via the PI3K/MAPK/NF-κB Pathway.

ABSTRACT: Treating acute lung injury (ALI) presents significant challenges due to adverse drug reactions. This study systematically explored the protective effects and mechanisms of a flavonoid-rich extract from Bombyx batryticatus (FBB), a traditional Chinese medicine, in combating ALI. Through UPLC-MS/MS analysis, we identified 163 flavonoid components in FBB for the first time, including flavonoids, flavonols, and chalcones. Unlike single-component flavonoid therapies, FBB provides synergistic regulation across multiple targets and pathways. Network pharmacology predictions, supported by experimental validation, revealed that FBB primarily suppresses the expression of inflammatory factors (IL-1β, IL-6, TNF-α) and oxidative stress markers (iNOS, COX-2) by modulating the PI3K/Akt, MAPK, and

SUBMITTER: Li W 

PROVIDER: S-EPMC12732911 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature