<i>Citri grandis</i> Exocarpium Extract Alleviates Atherosclerosis in ApoE^-/- Mice by Modulating the Expression of TGF-β1, PI3K, AKT1, PPAR-γ, LXR-α, and ABCA1.

ABSTRACT: Citri grandis exocarpium (Citri grandis) has been consumed by human beings for fifteen hundred years. It is commonly consumed as a health drink and dietary supplement in China. However, its nutritional and healthcare functions are still not fully understood. Objective: Our previous study found that oral administration of Citri grandis extract can significantly decrease the blood lipid levels of hyperlipidemic mice fed a high-fat diet. The aim of this study was to confirm the preventative effects of Citri grandis extract against atherosclerosis. Methods: Atherosclerotic lesion models were induced in HUVECs and apoE^-/- C57BL/6J mice. ApoE^-/- mice fed a high-fat diet were orally administered Citri grandis extract (0.4, 0.8

SUBMITTER: Xu J 

PROVIDER: S-EPMC12732995 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature