Synthesis of Novel Anion Recognition Molecules as Quinazoline Precursors.

ABSTRACT: Thiourea and structurally related urea derivatives are widely recognised for their ability to transport anions through hydrogen bonding interactions. The strength of these interactions correlates with the electronegativity of the ligand and the acidity of the NH hydrogens involved. Thiourea, being more acidic than urea, exhibits partial deprotonation in the presence of certain anions such as organic carboxylates, fluoride, and bromide, while remaining resistant to deprotonation by chloride. This behaviour suggests a degree of selectivity toward chloride ions. Additionally, while carbamide-containing molecules tend to aggregate-potentially reducing their ion-binding efficiency-thiourea derivatives show reduced aggregation, preserving their binding capabilities. In this study, we report the

SUBMITTER: Krajsovszky G 

PROVIDER: S-EPMC12733046 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature