Gene Regulation in Comorbid Migraine and Myogenic Temporomandibular Disorder Pain.

ABSTRACT:

Background/objectives

Previous studies have demonstrated an association between migraine headache and temporomandibular joint disorders (TMDs), with a higher prevalence of TMD symptoms in patients with migraine.

Methods

In this study, we conducted RNA sequencing to identify differentially expressed genes (DEGs) in the spinal trigeminal nucleus caudalis of mice with migraine-like pain and/or myogenic TMD.

Results

We observed 204 upregulated and 274 downregulated genes in the comorbid migraine and TMD group compared to the control group. We identified 15 ferroptosis-related DEGs enriched in the pathways of neurodegeneration, cellular homeostasis, interleukin signaling, and pain response. Gene Ontology analysis highlighted the involvement of neuroinflammatory response an

SUBMITTER: Tao R 

PROVIDER: S-EPMC12733123 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature