Investigation of Prothrombin G20210A and <i>Factor V Leiden</i> G1691A Variants in Patients with Acute Coronary Syndrome Presenting to the Emergency Department with Chest Pain.

ABSTRACT:

Background

Acute coronary syndrome (ACS) is a major cardiovascular emergency influenced by environmental and genetic factors. Thrombophilic variants such as prothrombin G20210A (rs1799963) and factor V Leiden G1691A (rs6025) may influence thrombin generation and has been reported to show associations with coronary events.

Methods

This case-control study included 100 ACS patients and 131 age and sex-matched healthy controls. Genotyping of rs1799963 and rs6025 was performed using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) analysis.

Results

The GG genotype was markedly more common among ACS patients for both variants. For rs1799963, carriers of the A allele (GA + AA) were less common in ACS (2.0%) than controls (9.2%;

SUBMITTER: Yukcu F 

PROVIDER: S-EPMC12733124 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature