Aqueous Extract of <i>Bacopa procumbens</i> and the NAPEL Formulation Mitigate MPTP-Induced Neurotoxicity via Nrf2/HSF1/HIF-1α Signaling in a Parkinson's Disease Model.

ABSTRACT: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron degeneration in the substantia nigra and striatum. Current treatments are largely palliative and frequently associated with adverse effects. This study aimed to evaluate the neuroprotective potential of an aqueous extract of Bacopa procumbens (B. procumbens) and the NAPEL formulation-composed of five neuroactive compounds (Naringenin, Apigenin, Paeoniflorin, (-)-Epicatechin, and Lupeol)-in a murine model of MPTP-induced parkinsonism. Behavioral, histological, and molecular parameters were examined to elucidate underlying mechanisms of neuroprotection. Male mice received MPTP to induce parkinsonism, followed by oral administration of B

SUBMITTER: Perez-Rodriguez M 

PROVIDER: S-EPMC12733197 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature