Proline-, Glutamic Acid-, Leucine-Rich Protein 1 (PELP1): Diversity, Structural Conservation, and Evolutionary Origins Across the Species.

ABSTRACT: Proline-, Glutamic acid-, Leucine-rich Protein 1 (PELP1) is a multifunctional nuclear protein essential for ribosome biogenesis and steroid receptor signaling. It contains two hallmark domains: the RIX1 (Ribosome Export 1) domain, which mediates rRNA processing, and the NUC (nucleolar) domain, associated with nucleolar function. While PELP1's biological roles are well-characterized in mammals, particularly Homo sapiens, its distribution, structural diversity, and evolutionary origin across the domain of life remain largely unexplored. This study addresses this gap by conducting a comprehensive data mining of PELP1 proteins across the NCBI, UniProt, and EukProt databases. A total of 646 PELP1 proteins were identified exclusively in eukaryotes, specifically within the Opisthokonta cla

SUBMITTER: Mngomezulu N 

PROVIDER: S-EPMC12733202 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature