Bridging East and West: Real-World Clinicogenomic Landscape of Metastatic NSCLC in Turkiye.

ABSTRACT:

Background/objectives

Genomic profiling guides treatment in metastatic non-small-cell lung cancer (mNSCLC), yet country-level data from Türkiye remain limited.

Methods

We retrospectively analyzed consecutive patients with mNSCLC diagnosed between January 2018 and March 2025 across tertiary centers in all seven regions. Variables included demographics, smoking, histology, testing modality (single-gene vs. next-generation sequencing [NGS]), targetable genomic alterations (TGAs) and co-mutations, and programmed death-ligand 1 (PD-L1) tumor proportion score.

Results

Among 1023 patients (mean age 64 years; 76.4% male), tobacco exposure was frequent (mean 42.1 pack-years); 16.9% were never-smokers. NGS use increased over time, exceeding 90% by 2025. TGAs were detected in 28

SUBMITTER: Canaslan K 

PROVIDER: S-EPMC12733280 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature