Catalytic Effect of Amyloid-β on Native Tau Aggregation at Physiologically Relevant Concentrations.

ABSTRACT: Alzheimer's disease (AD) is characterized by the accumulation and aggregation of tau and amyloid-β (Aβ). The pathophysiology and progression of AD are facilitated by the neurotoxic effects of these aggregated proteins, resulting in neurodegeneration and memory loss. In this context, the interaction between tau and Aβ42 is considered, but the mechanism underlying their pathogenic interplay remains unclear. Here, we addressed this question by studying the aggregation of full-length, unmodified tau and Aβ42 at physiologically low concentrations using atomic force microscopy (AFM). AFM imaging and data analyses demonstrate an increase in tau aggregation in the presence of Aβ42, characterized by increased sizes and number of aggregates. Importantly, tau aggregation occurs without the need for p

SUBMITTER: Chowdhury R 

PROVIDER: S-EPMC12733284 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature