Smart pH/Near-Infrared Light-Responsive Carboxymethyl Chitosan/Sodium Alginate/MXene Hydrogel Beads for Targeted Tea Polyphenols Delivery.

ABSTRACT: Tea polyphenols (TP) offer health benefits, but their stability is compromised by sensitivity to environmental factors, limiting their applications. Developing stimulus-responsive delivery systems that precisely control TP release is essential. This study prepared novel hydrogel beads encompassing carboxymethyl chitosan (CMC), sodium alginate (SA), and MXene (Ti₃C₂T_x) using a blending method for the sustained release of TP. After being exposed to 808 nm near-infrared (NIR) radiation, the beads demonstrated excellent stability in simulated gastric conditions, resulting from the pH-dependent solubilization, facilitating controlled TP release under simulated intestinal conditions. The drug release kinetics conformed to the Ritger-Peppas model. Notably, CMC-SA-

SUBMITTER: Fang K 

PROVIDER: S-EPMC12733298 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature