Chitosan/PEO Nanofibers as a Delivery Platform for Sustained Release of <i>Centella asiatica</i> Extract.

ABSTRACT: The search for multifunctional wound dressings that combine structural integrity with biological activity remains an important challenge in modern biomedicine. In this study, electrospun chitosan/polyethylene oxide (CS/PEO) nanofibers incorporating Centella asiatica extract were developed and evaluated in vitro as potential wound-healing materials. Nanofibers were fabricated using various CS/PEO ratios, and the 1:2 w/w composition loaded with 1% extract was selected as the optimal formulation based on morphological homogeneity and processing efficiency. Comprehensive characterization demonstrated that the nanofiber matrix provided sustained release of asiaticosides over several days, fitting best with Hixson-Crowell and Higuchi kinetic models, suggesting a combined diffusion-

SUBMITTER: Witkowska K 

PROVIDER: S-EPMC12733457 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature