Bowel Transit Time May Be Accelerated in Colonic Diverticulosis Independent of Mucosal Serotonin Signaling.

ABSTRACT: Background/Objectives: Colonic diverticulosis is a common condition in the elderly population and may affect bowel habits and reduce quality of life. Intestinal peristalsis is regulated by bioamines, which can influence bowel transit time. Methods: This prospective, comparative study included 23 patients. All participants were examined with colonoscopy with colonic mucosal biopsy and a bowel transit time test using SITZMARKS^® markers. The following bioamines were assessed in the colonic mucosa: 3-methoxy-4-hydroxyphenylglycol (MHPG), norepinephrine (NA), dopamine (DA), homovanillic acid (HVA), 5-hydroxytryptamine (5-HT, serotonin), and 5-hydroxyindoleacetic acid (5-HIAA). Results: Among study participants, 14 had colonic diverticulosis and 9 were controls. T

SUBMITTER: Nehring P 

PROVIDER: S-EPMC12733458 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature