L-Serine-Incorporated Collagen Scaffolds for Modulating In Vivo Degradation Behavior.

ABSTRACT: Collagen-based biomaterials are widely used, but their relatively rapid biodegradation can limit functional duration. Such collagen constructs are widely used as barrier membranes in guided tissue and bone regeneration, where controlled degradation is essential for maintaining function. Although conventional crosslinking methods extend stability, they may introduce cytotoxicity, alter mechanical behavior, or hinder tissue integration. This study evaluated whether incorporating L-serine, a polar amino acid capable of hydrogen bonding, could modulate collagen structure and slow degradation without chemical crosslinking. L-Serine was selected because its hydroxyl-containing side chain can engage in biocompatible, hydrogen-bond-mediated interactions that offer a mild, non-crosslinking means of

SUBMITTER: Kim SY 

PROVIDER: S-EPMC12733836 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature