Evaluation of Composites Comprising Spherical, Porous, Sintered β-Tricalcium Phosphate Particles and Cyanoacrylate as Bone Cement.

ABSTRACT: Bone cements based on polymethyl methacrylate (PMMA) remain the clinical standard for joint replacement and vertebral augmentation but suffer from several major challenges. These include excessive stiffness compared with cancellous bone, lack of resorption and osteoconductivity, and thermal necrosis during curing. Calcium phosphate cements (CPCs) are bioactive and resorbable but tend to exhibit low mechanical strength, poor injectability and brittle fracture. The work reported herein developed an injectable composite bone cement by combining spherical, porous, sintered β-tricalcium phosphate (β-TCP) particles with a cyanoacrylate adhesive. The β-TCP granules provided bioactivity and a favorable microarchitecture while the cyanoacrylate ensured strong adhesion and rapid setting. Ion substit

SUBMITTER: Hashimoto K 

PROVIDER: S-EPMC12733878 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature