Cationic Surface Modification Combined with Collagen Enhances the Stability and Delivery of Magnetosomes for Tumor Hyperthermia.

ABSTRACT: Magnetosomes (MTS), membrane-enclosed magnetic nanoparticles naturally biomineralized by magnetotactic bacteria, are promising materials for tumor hyperthermia owing to their good biocompatibility and heating efficiency. However, their application is limited by poor suspension stability and low injectability at high concentrations. This study aimed to enhance magnetosome stability and delivery performance through surface cationization combined with collagen matrix stabilization. The resulting cationic magnetosomes (CMTS) exhibited an increased positive charge on the outer membrane. Collagen, functioning as a negatively charged matrix under mildly alkaline conditions, effectively stabilized the cationic magnetosomes, forming CMTS-collagen aqueous suspensions (CMTS-Colas) that remained well-

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12733886 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature