Development and Validation of an Acute Large Animal Model for Type A Aortic Dissection.

ABSTRACT:

Background

Animal models are essential for translating diagnostic and therapeutic strategies into clinical practice and offer valuable insights into the pathophysiology of diseases such as aortic dissection. This study presents a novel acute in vivo large animal model of Stanford type A aortic dissection, combining open surgical access with endovascular techniques to leverage the advantages of both. The model aims to reproducibly simulate acute dissections in swine, providing a standardized platform for evaluating diagnostics, disease mechanisms, and treatment strategies.

Methods

Six pigs underwent a standardized protocol to induce aortic dissection. Arterial pressure was monitored via femoral and carotid catheterization. A conventional sternotomy was performed, followed by

SUBMITTER: Deniz E 

PROVIDER: S-EPMC12733893 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature