The Effects of Trifluoroacetic Acid (TFA) in Humans: A Rapid Review.

ABSTRACT: Human studies involving exposure to trifluoroacetic acid (TFA) and the associated clinical outcomes are typically not considered in standard chemical toxicity assessments. This review aimed to identify and synthesize all available human data on TFA exposure, regardless of study design or context. Given TFA's long-standing use and its formation as a degradation product of various compounds, a wide range of exposure scenarios was considered, including post-anesthesia monitoring, environmental assessments, and chemical incidents. The database searches in MEDLINE (PubMed) and EMBASE (Scopus) were conducted on 28 and 29 April 2025. A total of 17 studies met the inclusion criteria: 4 case reports, 3 case series, 5 observational studies, and 5 pharmacokinetic studies. All studies documented clear

SUBMITTER: Wipplinger J 

PROVIDER: S-EPMC12733928 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature