Urinary KIM-1 for Early Detection of Acute Kidney Injury in Neonates: A Systematic Review and Meta-Analysis.

ABSTRACT: Acute kidney injury (AKI) is a significant clinical concern in neonates, threatening optimal outcomes. Early and accurate diagnosis is crucial; however, current methods lack sufficient sensitivity. This meta-analysis aimed to evaluate urinary kidney injury molecule-1 (uKIM-1) for AKI in neonates by quantifying differences in uKIM-1 levels between AKI and non-AKI neonates. We systematically searched major databases for comparative studies. Quality assessment was performed using the Newcastle-Ottawa Scale, and the certainty of the evidence was assessed according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. A random-effects meta-analysis estimated the pooled Hedges' g in uKIM-1 levels, accounting for heterogeneity. Subgroup analyses explored so

SUBMITTER: Praditaukrit M 

PROVIDER: S-EPMC12733929 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature