Enhanced Benefits of Prone Positioning Combined with Lung Recruitment Maneuver in Patients with COVID-19 and Non-COVID-19 ARDS: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT: Background: Early reports highlighted unique features of COVID-19-associated ARDS. The combination of prone position (PP) and positive end-expiratory pressure (PEEP)-induced lung recruitment maneuver (LRM) has demonstrated efficacy in enhancing oxygenation and improving outcomes in patients with ARDS, but it remains unknown whether there is a difference between COVID-19 ARDS and non-COVID-19 ARDS. Method: This study is a secondary analysis of a previously conducted randomized controlled trial. Patients with moderate to severe ARDS were consecutively enrolled during the study period (June-December 2023). After initiation of PP, patients received a PEEP-induced LRM followed by 12 h of daily PP. The interventions were repeated at least three times over the subsequent 3 days. Cli

SUBMITTER: Lan L 

PROVIDER: S-EPMC12733944 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature