Comparative Analysis of Two-Lead DX-Based CRT Versus Conventional Three-Lead CRT-D: Results from a Single-Center Prospective Study.

ABSTRACT: Background/Objectives: Cardiac resynchronization therapy with defibrillator (CRT-D) is a well-established therapy for patients with heart failure (HF) and intraventricular conduction delays, but a non-negligible risk of infection and of lead functionality loss overtime is related to intravascular hardware. The novel DX system enables atrial sensing through a floating dipole integrated into the ICD lead, reducing the intravascular burden. In this prospective non-randomized study, we aimed to evaluate the safety and efficacy of a two-lead DX-based CRT system compared to a conventional three-lead (3L) CRT-D system. Methods: A total of 210 patients meeting CRT indications and no signs of sick sinus syndrome (SSS) (baseline HR ≥ 45 bpm, or at least 85 bpm at 6 min walking test) we

SUBMITTER: Carecci A 

PROVIDER: S-EPMC12733999 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature