Therapeutic Strategies for Abdominal Aortic Aneurysm: A Comprehensive Systematic Review.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) is a life-threatening condition with no proven pharmacological treatment to halt its progression. While animal models offer insights into pathophysiology and drug response, clinical translation remains limited.

Methods

We conducted a systematic review of repurposed drugs, classified by Anatomical Therapeutic Chemical (ATC) codes, tested in animal models for their effects on AAA progression. Following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and a PROSPERO-registered protocol (CRD42024323430), we screened 14,127 articles and included 144 studies across 13 of the 14 ATC categories.

Results

Most drug classes, particularly cardiovascular, metabolic, and immunomodulatory agents-includi

SUBMITTER: Kavaliunaite E 

PROVIDER: S-EPMC12734017 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature