Antifungal Susceptibility and Resistance-Associated Gene Expression in Nosocomial <i>Candida</i> Isolates.

ABSTRACT: Background: Nosocomial infections represent a significant clinical burden due to high morbidity, mortality and healthcare costs. Invasive fungal infections, particularly those caused by Candida species, are of growing concern due to increasing antifungal resistance, which limits therapeutic options and worsens patient outcomes. This study aimed to characterize the prevalence, species distribution, antifungal susceptibility profiles, and molecular mechanisms of resistance in clinical Candida isolates from hospitalized patients. Methods: A cross-sectional study was conducted involving 55 hospitalized patients, yielding 60 isolates from blood, secretions, fluids, and catheter tips. Species identification was performed using chromogenic media and confirmed by MALDI-

SUBMITTER: Hernandez-Reyes FB 

PROVIDER: S-EPMC12734134 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature