Real-World Outcomes of Treatment Approaches and the Impact of Systemic Inflammation Markers on Survival in Patients with Locally Advanced and Metastatic Laryngeal Cancer.

ABSTRACT: Background: Systemic inflammation and nutritional status have emerged as promising prognostic indicators across various malignancies; however, their clinical relevance in advanced laryngeal cancer remains underexplored. This study aimed to evaluate the prognostic significance of inflammation- and nutrition-based indices on the overall survival (OS) and progression-free survival (PFS) in patients with locally advanced or metastatic laryngeal cancer. Methods: A total of 147 patients treated at Pamukkale University between 2013 and 2022 were retrospectively analyzed. Baseline hematologic and biochemical parameters were used to calculate the Naples Prognostic Score (NPS), the Controlling Nutritional Status (CONUT) score, the Systemic Immune-Inflammation Index (SII), the Systemic

SUBMITTER: Cakan Demirel B 

PROVIDER: S-EPMC12734149 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature