Cytotoxicity and Genotoxicity of Resin-Based Dental Composites Modified with Quaternary Ammonium Salts.

ABSTRACT: The primary reason of dental restoration failure is the recurrence of caries, driving research to incorporate quaternary ammonium salts (QASs) into resin-based composites (RBCs). Given the prolonged contact of these materials with oral tissue, this in vitro study assessed the biocompatibility (cytotoxicity and genotoxicity) profiles of experimental RBCs modified with cetyltrimethylammonium bromide (CTAB) and dimethyldioctadecylammonium bromide (DODAB), using two restorative materials: an unmodified-experimental composite, KE, and Flow-Art (FA) as comparative standards. The primarily novelty of this study is the direct comparison of the cellular safety profiles of CTAB vs. DODAB when incorporated into RBCs. Human fibroblast BJ cells were exposed to composite eluates for 24 h, and cell viabi

SUBMITTER: Szymczak-Pajor I 

PROVIDER: S-EPMC12734297 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature