MAPK Pathways Coordinate Stress Adaptation by Mobilizing Specialized Gene Modules in Entomopathogenic Fungus <i>Beauveria bassiana</i>.

ABSTRACT: Mitogen-activated protein kinase (MAPK) cascades are critical for fungal development, stress adaptation. and virulence. However, their dynamic and stress-specific regulatory networks in entomopathogenic fungi remain largely unresolved. This study systematically investigates the roles of all three key MAPKs-BbHog1, BbSlt2, and BbMpk1-in insect pathogenic fungus Beauveria bassiana. A combination of detailed phenotypic profiling of deletion mutants (ΔBbHog1, ΔBbSlt2, and ΔBbMpk1) and time-course transcriptomics (RNA-seq at 0, 0.5, and 12 h) under osmotic, cell-wall, oxidative, and thermal stress conditions was employed, followed by weighted gene co-expression network analysis (WGCNA). This approach delineated twelve stress-responsive gene modules regulated by those

SUBMITTER: Huang S 

PROVIDER: S-EPMC12734328 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature