Skin Autofluorescence and Perinatal Outcomes in Pregnant Women with a Positive Glucose Challenge Test: A Prospective Study with Exploratory Analyses of Oxidative Stress and CGM Metrics.

ABSTRACT: Background/Objectives: Skin autofluorescence (SAF), a marker of advanced glycation end products (AGEs), reflects cumulative hyperglycemia and may predict vascular complications in diabetes. Continuous glucose monitoring (CGM) also provides detailed glycemic profiles, but their prognostic values in gestational diabetes mellitus (GDM) are unclear. The primary aim was to evaluate whether SAF predicts adverse maternal or neonatal outcomes, whereas secondary exploratory analyses assessed oxidative stress markers and CGM-derived metrics. Methods: We prospectively enrolled 115 Japanese pregnant women with plasma glucose ≥ 140 mg/dL at 60 min after 50-g GCT. At around 29 weeks' gestation, SAF and diacron-reactive oxygen metabolites (d-ROMs) were measured, and a subset underwent 14-da

SUBMITTER: Kakuto Y 

PROVIDER: S-EPMC12734361 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature