Association Between Serum Ionized Calcium Levels and Neurological Outcomes in Patients with Out-of-Hospital Cardiac Arrest.

ABSTRACT: Despite advances in post-cardiac arrest care, mortality and poor neurological outcomes remain common after out-of-hospital cardiac arrest (OHCA). Calcium imbalance is characteristic of post-cardiac arrest syndrome, but its prognostic role is unclear. We retrospectively analyzed 421 OHCA patients treated with targeted temperature management (TTM) (2011-2023). pH-adjusted ionized calcium levels were measured at 0, 12, 24, 48, and 72 h after return of spontaneous circulation (ROSC). Associations with 30-day neurological outcomes and mortality were assessed using multivariable logistic regression with two-stage maximum likelihood estimation. Higher baseline-adjusted ionized calcium levels were significantly associated with better neurological outcomes (Cerebral Performance Category 1-2) and lo

SUBMITTER: Park SY 

PROVIDER: S-EPMC12734376 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature