The Heterogeneous Interplay Between Metabolism and Mitochondrial Activity in Colorectal Cancer.

ABSTRACT: Background: Colorectal cancer is a multifactorial malignancy implicating a wide variety of risk factors, such as genetic, environmental, nutritional, and lifestyle factors, leading to a certain heterogeneity in the development of the disease. Colorectal cancer is generally classified in terms of a Warburg metabolic phenotype, characterized by an excess of glycolytic axes as compared to oxidative phosphorylation. It is therefore important to better characterize the metabolic heterogeneity of these tumors in relation to their mitochondrial activity. Materials and Methods: Two R-packages (keggmetascore and mitoscore) were developed to explore metabolism, based on KEGG metabolism pathways, and mitochondrial activities, based on mitocarta V3 annotations, for the investigation of d

SUBMITTER: Desterke C 

PROVIDER: S-EPMC12734392 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature