Plasma Metabolite Profiles of Children with Autism Spectrum Disorder.

ABSTRACT: Background/Objectives: Autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social and communication differences, is complex and aetiologically heterogeneous. Untargeted metabolomics is emerging as a tool in screening for biochemical abnormalities. This research was conducted using the Australian Autism Biobank resource and involved analysis of plasma metabolites to characterise metabolite differences between autistic children and controls. Methods: We sought to identify molecular signatures in the plasma of study subjects using mass-spectrometry methods. We included 955 untargeted plasma metabolites from autistic children (n = 491; 2-18 years; 78% male) and control subjects (n = 97; 2-17 years of age; 51% male). Statistical analyses were per

SUBMITTER: Mullin BH 

PROVIDER: S-EPMC12734473 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature