"Hyphae Intertwined, Biomolecules Co-Born"-New Polyketides Induction by Co-Culture of the Mangrove Endophytic Fungus <i>Phomopsis asparagi</i> DHS-48 and <i>Pestalotiopsis</i> sp. HHL-101 at Both Volatile and Non-Volatile Levels.

ABSTRACT: The co-culture technique, mimicking natural microbial interactions, has proven to be successful at activating silent biosynthetic gene clusters (BGCs) to produce novel metabolites or enhance the yield of specific metabolites. To effectively decode induction processes, it is critical to have a comprehensive understanding of intermicrobial interactions across both volatile and non-volatile metabolomes. As part of our attempt to uncover structurally unique and biologically active natural products from mangrove endophytic fungi, Phomopsis asparagi DHS-48 was co-cultured with another mangrove fungal strain, Pestalotiopsis sp. HHL-101. The competition interaction of the two strains was investigated using morphology and scanning electron microscopy (SEM), and it was discovered that

SUBMITTER: Feng T 

PROVIDER: S-EPMC12734679 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature